Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site

摘要

Cand1 can be separated into two functional polypeptides. C-terminal Cand1 binds first at the cullin adaptor site. N-terminal Cand1 blocks the neddylation site subsequently. Defects in the split fungal Cand1 impair development more than defects in CSN.